Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p 53 Takafumi Miyamoto
نویسندگان
چکیده
Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan. Cancer Proteomics Group, Genome Center, Japanese Foundation for Cancer Research, Tokyo, Japan. Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan. *Corresponding author. Email: [email protected]
منابع مشابه
Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53
The transcription factor p53 is at the core of a built-in tumor suppression system that responds to varying degrees of stress input and is deregulated in most human cancers. Befitting its role in maintaining cellular fitness and fidelity, p53 regulates an appropriate set of target genes in response to cellular stresses. However, a comprehensive understanding of this scheme has not been accompli...
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Melanomas and other cancers that do not express argininosuccinate synthetase (AS), the rate-limiting enzyme for arginine biosynthesis, are sensitive to arginine depletion with pegylated arginine deiminase (ADI-PEG20). However, ADI resistance eventually develops in tumors because of AS upregulation. Although it has been shown that AS upregulation involves c-Myc, the underlying mechanisms remain ...
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Melanomas and other cancers that do not express argininosuccinate synthetase (AS), the rate-limiting enzyme for arginine biosynthesis, are sensitive to arginine depletion with pegylated arginine deiminase (ADI-PEG20). However, ADI resistance eventually develops in tumors because of AS upregulation. Although it has been shown that AS upregulation involves c-Myc, the underlying mechanisms remain ...
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The levels of L-arginine, a cationic, semi-essential amino acid, are often controlled within a cell at the level of local availability through biosynthesis. The importance of this temporal and spatial control of cellular L-arginine is highlighted by the tissue specific roles of argininosuccinate synthase (argininosuccinate synthetase) (EC 6.3.4.5), as the rate-limiting step in the conversion of...
متن کاملKeyword Index for Volume 106
20S proteasome 904 22Rv1 166 4EGI-1 1660 8-oxodG 344 ABCB1 1395 ABCG2 1320 abdominal cancer 490 ABL1 157 acidity 1280 acute myeloid leukaemia 475 adenoma 517 adenosine triphosphate-based chemotherapy response assay 53 adhesion 1535 Adjuvant! Online 1760 adjuvant 32 adjuvant chemotherapy 1239, 1268 advanced 1068 advanced breast cancer 440 advanced gastric cancer 1039 afatinib 6 age 1068, 1353 AI...
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تاریخ انتشار 2017